Comments on: Heart Disease and Sleep http://www.your-heart-disease-blog.com/heart-disease-causes/heart-disease-and-sleep-49/?utm_source=rss&utm_medium=rss&utm_campaign=heart-disease-and-sleep Thu, 15 Sep 2011 20:54:25 +0000 hourly 1 http://wordpress.org/?v=3.1.1 By: CJ - Lipistat http://www.your-heart-disease-blog.com/heart-disease-causes/heart-disease-and-sleep-49/#comment-1776 CJ - Lipistat Mon, 26 May 2008 21:20:50 +0000 http://www.your-heart-disease-blog.com/heart-disease-causes/heart-disease-and-sleep-49/#comment-1776 What worries me the most about all the recent and past studies is, I doubt that every single person is the same. I know 75 year olds that have worked hard their whole life and ran on 5 hours of sleep and I know 75 year olds who've been lazy their whole life and still love to sleep. In both groups there are healthy people and in both groups there are unhealthy people. I'd assume that trying to stay rested, exercising regularly and eating right all leads to the best quality of life for each individual BUT the "quality of life" has more to do with genetics than anything else. Great post and certainly made me think about going to be early:) What worries me the most about all the recent and past studies is, I doubt that every single person is the same. I know 75 year olds that have worked hard their whole life and ran on 5 hours of sleep and I know 75 year olds who’ve been lazy their whole life and still love to sleep. In both groups there are healthy people and in both groups there are unhealthy people.

I’d assume that trying to stay rested, exercising regularly and eating right all leads to the best quality of life for each individual BUT the “quality of life” has more to do with genetics than anything else.

Great post and certainly made me think about going to be early:)

]]> By: vibhor Kumar http://www.your-heart-disease-blog.com/heart-disease-causes/heart-disease-and-sleep-49/#comment-529 vibhor Kumar Wed, 26 Sep 2007 22:06:13 +0000 http://www.your-heart-disease-blog.com/heart-disease-causes/heart-disease-and-sleep-49/#comment-529 Heart disease and sleep may have some correlation, but unless there is an explanation on molecular level, it is hard to confirm it. Recently in our laboratory, we have solved the structure of LDL (low density lipoprotein) to the resolution of 12-15 Angstorm using Cryo electron microscopic technique. We have also achieved its main protein's apob-100 consensus folding. We have also observed the variation in LDL structure that leads to its accumulation in blood plasma. The variations are mainly dependent upon size and quality of lipids, which inturn is also affected by food habits and living habits. People with busy life dont spent some of the harmones made using cholesterol and mostly spend time in sedentry works. However people with normal life, properly exaust their cholesterol derived harmones, like testosterone, vitamin D etc. It is also a matter of blood circulation difference (between sleep and awake) which also governs the quanitity of LDL in blood. Overall we found that misfolding of apoB-100 is the direct reason for not being taken by fibroblast tissues, but other factors do have role in affecting it. Overall there is a need of combination of moelcular level obsevation and statistical observation to derive more information from the structure we obtained. Heart disease and sleep may have some correlation, but unless there is an explanation on molecular level, it is hard to confirm it.
Recently in our laboratory, we have solved the structure of LDL (low density lipoprotein) to the resolution of 12-15 Angstorm using Cryo electron microscopic technique. We have also achieved its main protein’s apob-100 consensus folding. We have also observed the variation in LDL structure that leads to its accumulation in blood plasma. The variations are mainly dependent upon size and quality of lipids, which inturn is also affected by food habits and living habits. People with busy life dont spent some of the harmones made using cholesterol and mostly spend time in sedentry works. However people with normal life, properly exaust their cholesterol derived harmones, like testosterone, vitamin D etc.
It is also a matter of blood circulation difference (between sleep and awake) which also governs the quanitity of LDL in blood.
Overall we found that misfolding of apoB-100 is the direct reason for not being taken by fibroblast tissues, but other factors do have role in affecting it.
Overall there is a need of combination of moelcular level obsevation and statistical observation to derive more information from the structure we obtained.

]]>